Human testes, seminoma: immunohistochemical staining for Oct-3/4. Note nuclear staining of neoplastic cells. Oct-3/4: clone N1NK

Oct-3/4

oct-34

Antigen Background

Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin.

Disclaimer

Oct-3/4 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces OCT3/4-LOCT3/4-L-CE-SOCT3/4-L-S
    OCT3/4-L-CE
    1ml NCL-L-OCT3/4
    N1NK
    Liquid Concentrate
    P (HIER)
  • PA0193
    7ml Oct-3/4 (N1NK) Bond RTU Primary
    N1NK
    BOND RTU
    P (HIER)
  • PA0934
    7ml Oct-3/4 Bond RTU Primary
    N1NK
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

OCT3/4-L-CE
Gynepathology
N1NK
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0193
Gynepathology
N1NK
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0934
Gynepathology
N1NK
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

OCT3/4-L-CE
PA0193
PA0934

Resources

Resources

Antigen Background

Oct-3/4 is a member of the POU homeodomain family of transcription factors, which is expressed by embryonic stem cells and germ cells. A critical amount of Oct-3/4 is required to maintain stem cell self replication. Down regulation of Oct-3/4 levels are associated with loss of pluripotency. Oct-3/4 has been proposed as a useful marker for germ cell tumors which exhibit features of pluripotentiality, including seminoma/dysgerminoma/germinoma and embryonal carcinoma, and establishing a germ cell origin for some metastatic tumors of uncertain primary origin.

Disclaimer

Oct-3/4 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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