Human testis: immunohistochemical staining for inhibin alpha showing cytoplasmic staining of Sertoli cells. Inhibin Alpha: clone R1

Inhibin Alpha

inhibin-alpha

Antigen Background

Inhibins and activins are members of the transforming growth factor beta (TGFβ) family of cytokines. Inhibins are heterodimers consisting of a common α-subunit linked to either a βA subunit ( α-βA, forming inhibin A) or a βB subunit ( α-βB, forming inhibin B). Activins share the β-subunit with the inhibins and may be homo or heterodimers of β-subunits forming activin A (βA-βA), activin AB (βA-βB) or activin B (βB-βB). The expression of the α-subunit, and therefore of inhibins appears to be more restricted than that of the β-subunit, and therefore of activins. Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone (FSH) secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male. Inhibins are thought to have local regulatory roles in a variety of tissues, in addition to the ovary, including the brain, adrenal glands, bone marrow, fetus and placenta.

Disclaimer

Inhibin Alpha is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces INHIBINA-L-CE-SINHIBINA-LINHIBINA-L-S
    INHIBINA-L-CE
    1ml NCL-L-InhibinA
    AMY82
    Liquid Concentrate
    P (HIER)
  • This item replaces PA0110
    PA0488
    7ml Inhibin A (R1) Bond RTU Primary
    R1
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

INHIBINA-L-CE
Gynepathology
AMY82
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0488
Gynepathology
R1
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

INHIBINA-L-CE
PA0488

Resources

Resources

Antigen Background

Inhibins and activins are members of the transforming growth factor beta (TGFβ) family of cytokines. Inhibins are heterodimers consisting of a common α-subunit linked to either a βA subunit ( α-βA, forming inhibin A) or a βB subunit ( α-βB, forming inhibin B). Activins share the β-subunit with the inhibins and may be homo or heterodimers of β-subunits forming activin A (βA-βA), activin AB (βA-βB) or activin B (βB-βB). The expression of the α-subunit, and therefore of inhibins appears to be more restricted than that of the β-subunit, and therefore of activins. Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone (FSH) secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male. Inhibins are thought to have local regulatory roles in a variety of tissues, in addition to the ovary, including the brain, adrenal glands, bone marrow, fetus and placenta.

Disclaimer

Inhibin Alpha is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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