Mucins are heavily glycosylated glycoproteins which constitute the major components of mucus that covers the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have shown that these mucins are differentially expressed in epithelia with cell-type specificity. The normal gastric mucosa shows cell-type specific expression of Muc-1, Muc-5AC and Muc-6 glycoproteins with the first two mucins found in superficial epithelium and Muc-6 glycoprotein in the deep glands. Muc-1 and Muc-5AC glycoproteins are expressed in many epithelia but Muc-6 glycoprotein is mainly expressed in gastric mucosa. In addition, Muc-2 glycoprotein is not expressed in normal gastric mucosa.
PA0051, PA0052 and PA0053 are for use with BDD v 75 for BOND Software version 5.1 and higher. Please contact your local Leica Biosystems Representative with any questions.
Muc Glycoprotein Antibodies is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.