Human endometrium: immunohistochemical staining for Muc-1. Note luminal cytoplasmic staining of superficial epithelial cells and glandular epithelium. Muc-1 Glycoprotein: clone Ma695

Muc Glycoprotein Antibodies

muc-glycoprotein-antibodies

Antigen Background

Mucins are heavily glycosylated glycoproteins which constitute the major components of mucus that covers the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have shown that these mucins are differentially expressed in epithelia with cell-type specificity. The normal gastric mucosa shows cell-type specific expression of Muc-1, Muc-5AC and Muc-6 glycoproteins with the first two mucins found in superficial epithelium and Muc-6 glycoprotein in the deep glands. Muc-1 and Muc-5AC glycoproteins are expressed in many epithelia but Muc-6 glycoprotein is mainly expressed in gastric mucosa. In addition, Muc-2 glycoprotein is not expressed in normal gastric mucosa.

Product Notification

PA0051, PA0052 and PA0053 are for use with BDD v 75 for BOND Software version 5.1 and higher. Please contact your local Leica Biosystems Representative with any questions.

Disclaimer
Muc Glycoprotein Antibodies is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces MUC-2MUC-2-CE
    PA0155
    7mL Muc-2 (CCP58) Bond RTU Primary
    CCP58
    BOND RTU
    P (HIER)
  • PA0052
    7mL Muc-5AC Glycoprotein (CLH2) Bond RTU
    CLH2
    BOND RTU
    P (HIER)
  • PA0053
    7mL Muc-6 Glycoprotein (CLH5) Bond RTU
    CLH5
    BOND RTU
    P (HIER)
  • PA0051
    7ml Muc-1 Glycoprotein (Ma695) Bond RTU
    Ma695
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

PA0155
Gastrointestinal Pathology
CCP58
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0052
Gastrointestinal Pathology
CLH2
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0053
Gastrointestinal Pathology
CLH5
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0051
Gastrointestinal Pathology
Ma695
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

PA0155
PA0052
PA0053
PA0051

Resources

Resources

Antigen Background

Mucins are heavily glycosylated glycoproteins which constitute the major components of mucus that covers the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have shown that these mucins are differentially expressed in epithelia with cell-type specificity. The normal gastric mucosa shows cell-type specific expression of Muc-1, Muc-5AC and Muc-6 glycoproteins with the first two mucins found in superficial epithelium and Muc-6 glycoprotein in the deep glands. Muc-1 and Muc-5AC glycoproteins are expressed in many epithelia but Muc-6 glycoprotein is mainly expressed in gastric mucosa. In addition, Muc-2 glycoprotein is not expressed in normal gastric mucosa.

Product Notification

PA0051, PA0052 and PA0053 are for use with BDD v 75 for BOND Software version 5.1 and higher. Please contact your local Leica Biosystems Representative with any questions.

Disclaimer
Muc Glycoprotein Antibodies is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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