Human colonic adenocarcinoma: immunohistochemical staining for CDX2. Note the nuclear and cytoplasmic staining of malignant cells. CDX2: clone EP25

CDX2

cdx2

Antigen Background

CDX2 is a caudal-type homeobox, intestine-specific transcription factor expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. CDX2, as well as CDX1, is of particular interest as the intestine is the only organ that contains detectable levels of either gene product.

This pattern of restricted expression is unusual for homeobox genes. Phosphorylation of the CDX2 activation domain can modulate its function and different spatial expression patterns in the intestinal epithelium. CDX2 is primarily expressed on the surface of the villus and in the crypts. In contrast to CDX1, intense CDX2 expression is reported to occur in all but the distal portions of the developing intestine.

The loss of CDX2 has been reported to contribute towards the progression of some sporadic colorectal cancers. It has been reported that CDX2 may also be associated with carcinogenesis of the stomach as expression of CDX2 mRNA progressively decreases with the transition from well differentiated to poorly differentiated gastric cancer cell lines.

Disclaimer

CDX2 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • PA0375
    7ml CDX2 (EP25) Bond RTU Primary
    EP25
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

PA0375
Gastrointestinal Pathology
EP25
BOND RTU
Yes
P (HIER)
Mono
Rabbit
In Vitro Diagnostic Use
7ml

Documents

Documents

PA0375

Resources

Resources

Antigen Background

CDX2 is a caudal-type homeobox, intestine-specific transcription factor expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. CDX2, as well as CDX1, is of particular interest as the intestine is the only organ that contains detectable levels of either gene product.

This pattern of restricted expression is unusual for homeobox genes. Phosphorylation of the CDX2 activation domain can modulate its function and different spatial expression patterns in the intestinal epithelium. CDX2 is primarily expressed on the surface of the villus and in the crypts. In contrast to CDX1, intense CDX2 expression is reported to occur in all but the distal portions of the developing intestine.

The loss of CDX2 has been reported to contribute towards the progression of some sporadic colorectal cancers. It has been reported that CDX2 may also be associated with carcinogenesis of the stomach as expression of CDX2 mRNA progressively decreases with the transition from well differentiated to poorly differentiated gastric cancer cell lines.

Disclaimer

CDX2 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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