Human colon, gastrointestinal stromal tumor: immunohistochemical staining for DOG-1. Note membrane staining of neoplastic cells. DOG-1: clone K9

DOG-1

dog-1

Antigen Background

DOG-1, a 986 amino acid protein of unknown function, is expressed predominantly on the plasma membrane of gastrointestinal stromal tumors (GISTs) and is rarely expressed in other soft tissue tumors, which, due to appearance, can be confused with GISTs. Reactivity for DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen.

Product Specific Information

The use of PBS-based diluents may result in increased background staining.

Disclaimer
DOG-1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces DOG-1-L-CE-SDOG-1-L-S
    DOG-1-L-CE
    1ml NCL-L-DOG-1
    K9
    Liquid Concentrate
    P (HIER)
  • PA0219
    7ml DOG-1 Bond RTU Primary
    K9
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

DOG-1-L-CE
Gastrointestinal Pathology
K9
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0219
Gastrointestinal Pathology
K9
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

DOG-1-L-CE
PA0219

Resources

Resources

Antigen Background

DOG-1, a 986 amino acid protein of unknown function, is expressed predominantly on the plasma membrane of gastrointestinal stromal tumors (GISTs) and is rarely expressed in other soft tissue tumors, which, due to appearance, can be confused with GISTs. Reactivity for DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen.

Product Specific Information

The use of PBS-based diluents may result in increased background staining.

Disclaimer
DOG-1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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