Malignant Melanoma: Immunohistochemistry staining of S-100B scanned using the Aperio AT2. Nuclear and cytoplasmic staining in tumor cells. S-100B: clone EP32

S-100

s-100
Antigen Background

S-100A and S-100B proteins are two members of the S-100 family of proteins. S-100A subtypes are composed of one alpha and one beta chain, whereas S-100B is composed of two beta chains. S-100 protein is reported to be expressed in neuroectodermal tissue, including nerves and melanocytes. Langerhans cells in skin are also reported to express S-100 protein. It is noteworthy that S-100 protein is highly soluble and may be eluted from frozen tissue during immunohistochemical procedures.

Product Specific Information

Clone EP32 was raised against S-100 beta protein. Immunoreactivity was observed in neuroectodermal tissue e.g. melanocytes, nerve fibres, dendritic cells, adipocytes and a percentage of macrophages, lymphocytes and plasma cells.

Disclaimer

S-100 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
  • PA0031
    7mL S-100 (EP32) BOND RTU Primary
    EP32
    BOND RTU
    P (HIER)
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  • S100-167-L-CE
    1mL NCL-L-S100-167
    EP32
    Liquid Concentrate
    P (HIER)
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  • PA0900
    7ml S-100 Bond RTU Primary
    POLYCLONAL
    BOND RTU
    P (ENZYME)
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  • This item replaces S100P-L-CE-SS100P-R-7S100-SS100-US100S100P-L-S
    S100P-L-CE
    1ml NCL-L-S100p
    POLYCLONAL
    Liquid Concentrate
    P
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  • PA0820
    7ML (4C4.9 MAB) S100 Protein 'CM'
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Product Specifications

Product Specifications

PA0031
EP32
BOND RTU
Yes
P (HIER)
Mono
Rabbit
In Vitro Diagnostic Use
7ml
S100-167-L-CE
EP32
Liquid Concentrate
Yes
P (HIER)
Mono
Rabbit
In Vitro Diagnostic Use
1ml
PA0900
Dermatopathology
POLYCLONAL
BOND RTU
Yes
P (ENZYME)
Poly
Rabbit
In Vitro Diagnostic Use
7ml
S100P-L-CE
Dermatopathology
POLYCLONAL
Liquid Concentrate
Yes
P
Poly
Rabbit
In Vitro Diagnostic Use
1ml
PA0820

Documents

Documents

PA0031
S100-167-L-CE
PA0900
S100P-L-CE

Resources

Resources

Antigen Background

S-100A and S-100B proteins are two members of the S-100 family of proteins. S-100A subtypes are composed of one alpha and one beta chain, whereas S-100B is composed of two beta chains. S-100 protein is reported to be expressed in neuroectodermal tissue, including nerves and melanocytes. Langerhans cells in skin are also reported to express S-100 protein. It is noteworthy that S-100 protein is highly soluble and may be eluted from frozen tissue during immunohistochemical procedures.

Product Specific Information

Clone EP32 was raised against S-100 beta protein. Immunoreactivity was observed in neuroectodermal tissue e.g. melanocytes, nerve fibres, dendritic cells, adipocytes and a percentage of macrophages, lymphocytes and plasma cells.

Disclaimer

S-100 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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