Hybridization of DEK/NUP214 Fusion Probe to a positive cell line showing a fusion due to t(6;9).


The chromosomal translocation t(6;9) (p22;q34) is associated with a specific subtype of acute myeloid leukemia (AML) and constitutes 0.5% to 4% of all AML cases. The translocation results in a fusion between the DEK oncogene (6p22) and the nucleoporin 214 kDa (NUP214 at 9q34; previously known as CAN). The exact mechanism by which the fusion protein DEK-NUP214 contributes to leukemia development has not been identified. Patients with t(6;9) AML have a very poor prognosis. The DEK/NUP214 t(6;9) specific FISH probe has been optimized to detect the reciprocal translocation t(6;9) in a dual-color, dual-fusion assay on metaphase/interphase spreads, blood smears and bone marrow cells.

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