20q- (20q12) / 20q11 probe hybridized to patient material showing 20q- deletion (1R2G). Material kindly provided by Labdia Labordiagnostik, Vienna.
20q- (20q12) / 20q11 probe hybridized to patient material showing 20q- deletion (1R2G). Material kindly provided by Labdia Labordiagnostik, Vienna.
IVD 20q-
ID do produto
ivd-20q
Acquired deletions of the long arm of chromosome 20 are found in several hematologic conditions and particularly in the myeloproliferative disorders (MPD) and myelodysplastic syndromes and acute myeloid leukemia (MDS/AML). A minimal critical region deleted in MPD and MDS has been identified at 20q12 which includes a protein tyrosine phosphatase receptor gene. The 20q- (20q12) specific FISH probe is optimized to detect copy numbers of 20q at region 20q12. A 20q11 region specific probe is included to facilitate chromosome identification.
References: Bench et al, 2000, Oncogene, 19; 3902-3913. Asimakopoulos et al, 1994, Blood, 84; 3086-3094.
