Advancing Cancer Diagnostics, Improving Lives
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Hintergrund des Antigens
Das Ki67-Antigen ist ein nukleäres Protein, das in allen aktiven Teilen des Zellzyklus (G1, S, G2 und Mitose) exprimiert wird, in ruhenden Zellen (G0) jedoch nicht vorhanden ist.
Im Gegensatz zu zahlreichen anderen zellzyklusassoziierten Proteinen, ist das Ki67-Antigen in ruhenden Zellen durchgängig nicht vorhanden und bei DNA-Reparaturprozessen nicht nachweisbar.
Auf diese Weise wird die Präsenz des Ki67-Antigens streng mit dem Zellzyklus assoziiert und beschränkt sich auf den Zellkern, was auf eine wichtige Rolle bei der Erhaltung und/oder Regulierung des Zellteilungszyklus hindeutet.
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