FGFR1 (8p11) Break probe hybridization to a tissue section showing a normal pattern.

RUO - FGFR1 Break

FGFR1 has been implicated in the tumorigenesis of haematological malignancies, where it is frequently involved in balanced chromosomal translocations, including cases of chronic myeloid leukemia (BCR-FGFR1 fusion) and the 8p11 myeloproliferative syndrome/stem cell leukemia-lymphoma syndrome, which is characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, the most common being a fusion between ZNF198 and FGFR1. The FGFR1 (8p11) Break FISH probe is optimized to detect translocations involving the FGFR1 gene region at 8p11 in a dual-color assay on FFPE tissue sections.

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FGFR1 (8p11) Break
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