dic(9;20) Triple-Color. Image kindly provided by Dr. Ann Nordgren, Stockholm.

IVD dic(9;20)

The dic(9;20)(p13.2;q11.2) is a recurrent chromosomal abnormality in pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL), which occurs in ~2% of the cases. It is associated with an intermediate outcome with relapses being relatively frequent, compared to other common cytogenetic subgroups of BCP-ALL (e.g. high hyperploidy and t(12;21)). The dic(9;20) is an unbalanced rearrangement involving chromosomes 9 and 20, resulting in the co-localisation of the respective centromeres and concomitant loss of the chromosome arms 9p and 20q. The dic(9;20) Triple-Color FISH probe is optimized to detect the dicentric (9;20)(p13.2;q11.2) in a triple-color assay on metaphase/interphase spreads, blood smears and bone marrow cells.

Forestier et al., Genes Chromosome Cancer, 2008, 47; 149-158.
Pichler H et al., Br J Haematol, 2010, 149; 93-100.
Schmiegelow et al., Leukemia, 2010, 24; 345-54.
Zachariadis et al., Leukemia, 2011, 25; 22-628.
Zachariadis et al., Br J Haematol, 2012, 159; 488-491.



dic(9;20) Triple-Color
Contact Us for a quote.


Recently Viewed