RUO - 20q-

Acquired deletions of the long arm of chromosome 20 are found in several hematologic conditions and particularly in the myeloproliferative disorders (MPD) and myelodysplastic syndromes and acute myeloid leukemia (MDS / AML). A minimal critical region deleted in MPD and MDS has been identified at 20q12 which includes a protein tyrosine phosphatase receptor gene. The 20q- (20q12) specific FISH probe is optimized to detect copy numbers of 20q at region 20q12. A 20q11 region specific probe is included to facilitate chromosome identification.

References:
Bench et al, 2000, Oncogene, 19; 3902-3913.
Asimakopoulos et al, 1994, Blood, 84; 3086-3094.