ERCC1 (19q13) / ZNF443 (19p13) probe hybridized to paraffin embedded tissue (2R2G).

RUO - ERCC1 / ZNF443

ruo-ercc1-znf443
Excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC1) is a critical gene in the Nucleotide excision repair pathway. A growing list of reports links cisplatin, carboplatin, and oxaliplatin based chemotherapy resistance to ERCC1 expression levels in several tumors. ERCC1 has been shown to be an important marker to predict responsiveness to cisplatin-based chemotherapy. Low ERCC1 gene expression correlates with prolonged survival after cisplatin-based chemotherapy. The ERCC1 (19q13) FISH probe has been optimized to detect copy numbers of the ERCC1 gene region at 19q13. The ZNF443 (19p13) probe is included to facilitate chromosome identification.

References:
Olaussen et al, 2006, N. Engl. J. Med. 335; 983-991.
Ceppi et al, 2006, Ann. Oncol. 17; 1818-1825.
  • KI-10739
    ERCC1 (19q13) / ZNF443 (19p13)
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Product Specifications

Product Specifications

KI-10739
Research
Research Use Only
10 test
Dual Color > Red, Green
Tissue
Deletion Amplification
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

Documents

Documents

KI-10739

Resources

Resources

Excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC1) is a critical gene in the Nucleotide excision repair pathway. A growing list of reports links cisplatin, carboplatin, and oxaliplatin based chemotherapy resistance to ERCC1 expression levels in several tumors. ERCC1 has been shown to be an important marker to predict responsiveness to cisplatin-based chemotherapy. Low ERCC1 gene expression correlates with prolonged survival after cisplatin-based chemotherapy. The ERCC1 (19q13) FISH probe has been optimized to detect copy numbers of the ERCC1 gene region at 19q13. The ZNF443 (19p13) probe is included to facilitate chromosome identification.

References:
Olaussen et al, 2006, N. Engl. J. Med. 335; 983-991.
Ceppi et al, 2006, Ann. Oncol. 17; 1818-1825.

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