ATM (11q22) / GLI1 (12q13) hybridized to a normal metaphase (2R2G).
ATM (11q22) / GLI1 (12q13) hybridized to a normal metaphase (2R2G).
RUO - ATM / GLI1
Deletion of ATM at 11q22-q23 indicates a rather poor prognosis, amplification of GLI1 (previously known as GLI) at 12q13 is associated with an intermediate prognosis. The ATM (11q22) specific FISH probe is optimized to detect copy numbers of the ATM gene region at 11q22. The GLI1 (12q13) specific FISH probe is optimized to detect copy numbers of the GLI1 gene region at 12q13.
References: Doehner H et al, 1997, Blood, 7; 2516-2522. Boultwood J, 2001, J. Clin. Pathol., 54; 512-516. Dierlamm J et al, 1998, Genes Chromosomes Cancer, 20; 155-166. Doehner H at al, 1999, J. Molec. Med., 77; 266-281.
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