T-Cell Lymphoma: immunohistochemistry staining of CD4. Note the membrane staining of the tumor cells. CD4: clone 4B12

CD4

cd4

Antigen Background

The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes and at a lower level on monocytes and germinal center macrophages. Most cases of cutaneous T cell lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1 associated adult T cell leukemia/lymphoma is also generally CD4 positive.

Disclaimer

CD4 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • CD4-368-L-CE-H
    0.5ml NCL-L-CD4-368
    4B12
    Liquid Concentrate
    P (HIER)
  • This item replaces CD4-368-LCD4-1F6CD4-1F6-L-CECD4-1F6-CECD4-368CD4-368-L-ACD4-1F6-CE-SCD4-1F6-SCD4-1F6-R-7CD4-368-SCD4-368-L-SCD4-1F6-R-7-CECD4-1F6-OCD4-368-L-CE-S
    CD4-368-L-CE
    1ml NCL-L-CD4-368
    4B12
    Liquid Concentrate
    P (HIER)
  • This item replaces PA0368
    PA0427
    7ml CD4 (4B12) Bond RTU Primary
    4B12
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CD4-368-L-CE-H
Hematopathology
4B12
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
CD4-368-L-CE
Hematopathology
4B12
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0427
Hematopathology
4B12
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CD4-368-L-CE-H
CD4-368-L-CE
PA0427

Resources

Resources

Antigen Background

The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes and at a lower level on monocytes and germinal center macrophages. Most cases of cutaneous T cell lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1 associated adult T cell leukemia/lymphoma is also generally CD4 positive.

Disclaimer

CD4 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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