Advancing Cancer Diagnostics, Improving Lives
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Informações do antígeno
Oct3/4 é um membro da família de homeodomínios POU de fatores de transcrição, o qual é expressado por células-tronco embrionários e células germinativas. Uma quantidade crítica de Oct3/4 é requerida para manter a auto-replicação de células-tronco. A regulação decrescente dos níveis de Oct3/4 está associada com a perda de pluripotência.
O Oct3/4 foi proposto como um marcador útil para tumores de células germinativas que exibem características de pluripotencialidade, incluindo seminomo/disgerminoma/germinoma e carcinoma embrionário, e estabelecendo uma origem de célula germinativa para alguns tumores metastáticos de tumores primários incertos.
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