Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma are among the most common malignant soft tissue tumors presented in older adults. These tumors can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas. Amplification of the MDM2 gene has been identified in lipomatous neoplasms. The use of fluorescence in situ hybridization in identifying MDM2 amplification has made the MDM2 amplification probe a valuable diagnostic tool in well- differentiated liposarcomas/atypical lipomatous tumors. The MDM2 (12q15) FISH probe is optimized to detect copy numbers of the MDM2 gene region at region 12q15. The chromosome 12 satellite enumeration probe (SE 12) at D12Z3 is included to facilitate chromosome identification.
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