FGFR3 / IGH t(4;14) Fusion probe hybridized to MM patient material showing t(4;14) translocation (2RG1R1G). Image kindly provided by Prof. Jauch, Heidelberg.


The t(4;14) translocation is undetectable by conventional cytogenetics. The breakpoints on chromosome 4 occur within an approximately 113-kb region located in small part of a conserved gene cluster including the transforming acidic coiled-coil protein 3 (TACC3), fibroblast growth factor receptor 3 (FGFR3), and multiple myeloma SET domain-containing protein (MMSET). The translocation is indicative for poor survival and poor response to chemotherapy. The FGFR3 / IGH t(4;14)(p16;q32) Fusion specific FISH probe is optimized to detect the reciprocal translocation t(4;14) in a dual-color, dual-fusion assay.

Chesi et al, 1997, Nat Genet, 16; 260-264.
Finelli et al, 1999, Blood, 94; 724-732.

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