IVD FUS Break

The fused in sarcoma (FUS) gene was originally shown to be rearranged in myxoid liposarcomas harboring a t(12;16)(q13;p11) translocation. FUS has also been shown to be involved in other recombinations: with ERG in acute myeloid leukemia carrying a t(16;21), with ATF1 in band 12q13 in angiomatoid fibrous histiocytoma, and with CREB3L2 in fibromyxoid sarcoma. A break or split probe for FUS is best used to analyze translocation of the FUS (16p11) gene on formalin fixed paraffin embedded tissue for routine clinical diagnosis. The FUS (16p11) Break probe is optimized to detect translocations involving the FUS gene region at 16p11 in a dual-color, split assay on metaphase/interphase spreads and paraffin embedded tissue sections.

References:
Shing et al, 2003, Cancer Res, 63: 4568-4576.
Storlazzi et al, 2003, Hum. Mol. Genet., 12: 2349-2358.