Human skin, melanoma: immunohistochemical staining for HMB45. Note the melanoma showing strong cytoplasmic staining. Melanoma Marker (HMB45): clone HMB45

Melanoma Marker (HMB45)

Antigen Background

The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells.
Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation.

Product Specific Information

The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996)).

Disclaimer

Melanoma Marker (HMB45) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Products

Products

HMB45-L-CE
1ml NCL-L-HMB45
Country availability
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PA0625
30ml HMB45 Bond RTU Primary
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PA0027
7ml HMB45 Bond RTU Primary
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HMB45-L-U
1ml NCL-L-HMB45
Country availability
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PA0027-U
7ml HMB45 Bond RTU Primary
Country availability
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PA0625-U
30ml HMB45 Bond RTU Primary
Country availability
Contact Us for a quote.

Downloads

Downloads

HMB45-L-CE

PA0625

PA0027

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