NUP98

nup98

Nucleoporin 98kDa gene (NUP98) rearrangements have been identified in a wide range of hematologic malignancies, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia in blast crisis (CML-bc), myelodysplastic syndrome (MDS) and bilineage/ biphenotypic leukemia. The NUP98 gene is highly promiscuous with regard to its recombination spectrum, as at least 28 different partner genes have been identified for NUP98 rearrangements, all forming inframe fusion genes. Patients with NUP98 gene rearrangements have an aggressive clinical course and the outcome of treatment is disappointing.


Literature:
Gough et al, 2011, Blood 118; 62 47-6257.
Nebral et al, 2005, Haematologica 90; 74 6-752.
Romana et al, 2006, Leukemia 20; 696-70 6.

  • KBI-10311
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    NUP98 (11p15) Break
  • KI-10311
    查看可用性
    NUP98 (11p15) Break
  • KCN-10311
    查看可用性
    NUP98 (11p15) Break

产品规格

产品规格

KBI-10311
Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KI-10311
Research
Research Use Only
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KCN-10311
In Vitro Diagnostic Use

说明书

说明书

产品资料

产品资料

Nucleoporin 98kDa gene (NUP98) rearrangements have been identified in a wide range of hematologic malignancies, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia in blast crisis (CML-bc), myelodysplastic syndrome (MDS) and bilineage/ biphenotypic leukemia. The NUP98 gene is highly promiscuous with regard to its recombination spectrum, as at least 28 different partner genes have been identified for NUP98 rearrangements, all forming inframe fusion genes. Patients with NUP98 gene rearrangements have an aggressive clinical course and the outcome of treatment is disappointing.


Literature:
Gough et al, 2011, Blood 118; 62 47-6257.
Nebral et al, 2005, Haematologica 90; 74 6-752.
Romana et al, 2006, Leukemia 20; 696-70 6.

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