Hybridization of MET Amplification probe to a tissue section showing MET amplification.
IVD MET/SE 7
The MET proto-oncogene is a receptor-like tyrosine kinase that drives a physiological cellular program important for development, cell movement, cell repair and cellular growth. Aberrant execution of this program has been associated to neoplastic transformation, invasion and metastasis. Activation of MET has been reported in a significant percentage of human cancers including non-small cell lung cancer (NSCLC) and is amplified during the transition between primary tumors and metastasis. The MET (7q31) FISH probe is optimized to detect copy numbers of the MET gene region at region 7q31. The Chromosome 7 Satellite enumeration probe (SE 7) at D7Z1 is included to facilitate chromosome identification.
References: Go et al, 2010, J Thorac Oncol 5: 305-313. Hara et al, 1998, Lab Invest 78; 1143-1153. Tsugawa et al, 1998, Oncology 55; 475-481.