IRF4 / DUSP22 (6p25) Break. Image kindly provided by Hospital Universitario Marqués de Valdecilla, Satander.

RUO - IRF4 / DUSP22 Break

ruo-irf4-dusp22-break
Rearrangements of the 6p25.3 locus define a subtype of CTCL. Genes rearranged at the 6p25.3 locus are IRF4 (also known as MUM1) and the DUSP22. Rearrangements of the 6p25.3 locus have also been described to occur in high and low grade B-cell lymphomas, myeloma and chronic B-cell lymphoid leukemia.
The IRF4 / DUSP22 (6p25) Break FISH probe detects both rearrangements involving IRF4 and DUSP22, but does not distinguish them from each other. The IRF4 / DUSP22 (6p25) Break FISH probe is optimized to detect translocations involving the IRF4 / DUSP22 gene region at the 6p25.3 locus in a dual-color assay on metaphase/interphase spreads, blood smears, bone marrow cells and lymph node biopsies.

References:
Bisig et al., Best Pract Res Clin Haematol, 2012, 25; 13-28.
Feldman et al., Blood, 2011, 117; 915-919.
Karai et al., Am J Surg Pathol, 2013; 37; 1173-81.
Pham-Ledard et al., J Invest Dermatol, 2010, 130; 816-825.
Salaverria et al., Blood, 2011, 118; 139-147.
Wada et al., Mod Pathol, 2011, 24; 596-605.

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KI-10613
IRF4 / DUSP22 (6p25) Break
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