The MAFB / IGH t(14;20) Fusion FISH probe hybridized to patient material showing a complex pattern with a t(14;20) translocation. Image kindly provided by Erasmus Medical Center, Rotterdam.

IVD MAFB /IGH

ivd-mafb-igh
The immunoglobulin heavy chain (IGH) gene at 14q32 is an important cause of genetic deregulation in MM. Among the known fusion partners for the IGH (previously known as IGH@) gene, reciprocal translocation with the MAFB gene at 20q12 is relatively rare in MM (~2% occurrence). However, the MAFB/IGH t(14;20) translocation is associated with poor prognosis in multiple myeloma patients. The MAFB/IGH t(14;20) Fusion FISH probe is optimized to detect the reciprocal translocation t(14;20) in a dual-color, dual-fusion assay on metaphase/interphase spreads and bone marrow cells.

References:
Boersma-Vreugdenhil GR et al, 2004, Br J Haematol, 126; 355-363.
Bergsagel PL et al, 2005, JCO, 23; 6333-6338.

Products

Products

KBI-10510
ON MAFB/IGH@ t(14;20) Fusion
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Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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