FGFR1 (8p11) Break probe hybridization to a tissue section showing a normal pattern.

IVD FGFR1 Break

ivd-fgfr1-break
FGFR1 has been implicated in the tumorigenesis of haematological malignancies, where it is frequently involved in balanced chromosomal translocations, including cases of chronic myeloid leukemia (BCR-FGFR1 fusion) and the 8p11 myeloproliferative syndrome/stem cell leukemia-lymphoma syndrome, which is characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, the most common being a fusion between ZNF198 and FGFR1. The FGFR1 (8p11) Break FISH probe is optimized to detect translocations involving the FGFR1 gene region at 8p11 in a dual-color assay on FFPE tissue sections.

References:
Smedley et al, 1998, Hum Mol Genet., 7; 627-642.
Sohal et al, 2001, Genes Chrom. Cancer, 32; 155-163.
Kwak et al, J Clin Oncol., 27(26); 4247-53.

Products

Products

KBI-10737
ON FGFR1 (8p12) Break
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Breast Pathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Tissue
Translocation
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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