CDKN2A (9p21) / 9q21 hybridized to a metaphase spread showing a normal pattern (2R2G).

IVD CDKN2A/9q21

ivd-cdkn2a-9q21
Hemizygous deletions and rearrangements of chromosome 9, band p21 are among the most frequent cytogenetic abnormalities detected in pediatric acute lymphoblastic leukemia (ALL). This deletion includes loss of the CDKN2A (previously known as p16, INK4A or MTS1)/CDKN2B (previously known as p15, INK4B or MTS2) genes, which are cell cycle kinase inhibitors and important in leukemogenesis. The CDKN2A (9p21) specific FISH probe is optimized to detect copy numbers of the CDKN2A gene region at region 9p21. The 9q21 region probe is included to facilitate chromosome identification.

References:
Dreyling et al, 1995, Blood, 86; 1931-1938.
Southgate et al, 1995, Br J Cancer, 72; 1214-1218.

Products

Products

KBI-10402
ON p16 (9p21) / 9q21
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Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Deletion
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

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