BCR / ABL1 t(9;22),Triple-Color, Dual Fusion probe hybridized on patient material showing translocation of distal BCR (1BG1RB1R1G). Image kindly provided by Prof. Siebert, Kiel.
IVD BCR/ABL1 TC
The BCR/ABL1 t(9;22) FISH probe is a triple-color, dual-fusion probe built from the same regions as the dual-color, dual-fusion probe, but the proximal BCR region is labeled in blue. Using the triple-color probe allows to distinguish between the derivative chromosome 22, the Philadelphia chromosome, which will be observed as purple (red/blue) color, while the derivative chromosome 9 will show a yellow (red/green) signal.
References: Morris et al, 1990, Blood, 76; 1812-1818. Dewald et al, 1998, Blood, 91; 3357-3365. Kolomietz et al, 2001, Blood, 97; 3581-3588. Huntly et al, 2003, Blood, 102; 1160-1168. Tkachuk et al., 1990, Science, 250; 559-562.