Human skin, melanoma: immunohistochemical staining for HMB45. Note the melanoma showing strong cytoplasmic staining. Melanoma Marker (HMB45): clone HMB45

Melanoma Marker (HMB45)

melanoma-marker-hmb45

Antigen Background

The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells.
Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation.

Product Specific Information

The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996)).

Disclaimer

Melanoma Marker (HMB45) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • HMB45-L-CE
    1ml NCL-L-HMB45
    HMB45
    Liquid Concentrate
    P (ENZYME)
  • PA0625
    30ml HMB45 Bond RTU Primary
    HMB45
    BOND RTU
    P (ENZYME)
  • PA0027
    7ml HMB45 Bond RTU Primary
    HMB45
    BOND RTU
    P (ENZYME)

Produktspezifikationen

Produktspezifikationen

HMB45-L-CE
Dermatopathology
HMB45
Liquid Concentrate
Yes
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0625
Dermatopathology
HMB45
BOND RTU
Yes
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
30ml
PA0027
Dermatopathology
HMB45
BOND RTU
Yes
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Dokumente

Dokumente

Ressourcen

Ressourcen

Antigen Background

The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells.
Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation.

Product Specific Information

The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996)).

Disclaimer

Melanoma Marker (HMB45) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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