IVD FGFR1/SE 8

Amplification of the fibroblast growth factor receptor type 1 gene (FGFR1) has been observed in numerous cancer types including lung cancer (especially squamous cell carcinoma) and breast cancer. The FGFR1 (8p11)/SE 8 FISH probe is optimized to detect amplification involving the FGFR1 gene region at 8p11 in a dual-color assay on paraffin embedded tissue sections. The chromosome 8 satellite enumeration probe (SE 8) at D8Z1 is included to facilitate chromosome identification.

References:
Weiss et al, 2010, Sci Transl. Med. 2(62); 62ra93.
Brooks et al, 2012, Clin. Cancer res. 18(7): 1855-62.