BCL6 (3q27) Break probe hybridized to patient material (1RG1R1G). Image kindly provided by Prof. Siebert, Kiel.
BCL6 (3q27) Break probe hybridized to patient material (1RG1R1G). Image kindly provided by Prof. Siebert, Kiel.
IVD BCL6 Break
Chromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. Kreatech has developed this probe for the specific use on cell material (KBI-10607), or on tissue (KBI-10730). Two different breakpoint regions have been identified; the major breakpoint region (MBR) is located within the 5' noncoding region of the BCL6 proto-oncogene, while the atypical breakpoint region (ABR) is located approximately 200 kb distal to the BCL6 gene. The BCL6 (3q27) Break FISH probe is designed in a way to flank both possible breakpoints, thereby providing clear split signals in either case.
References: Butler et al, 2002, Cancer Res, 62; 4089-4094. Sanchez-Izquierdo, 2001, Leukemia, 15; 1475-1484.
