Advancing Cancer Diagnostics, Improving Lives
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Hintergrund des Antigens
Das CD20-Antigen ist ein nicht-glykosyliertes Phosphoprotein von etwa 33 kD, das auf normalen und malignen humanen B-Zellen exprimiert wird und von dem man annimmt, dass es als Rezeptor während der B-Zell-Aktivierung und -Differenzierung fungiert.
Die Expression des CD20-Antigens wurde auf normalen B-Zellen aus dem peripheren Blut, in Lymphknoten, Milz, Tonsillen, Knochenmark, bei akuten Leukämien und chronischen lymphatischen Leukämien nachgewiesen.
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