Mismatch repair gene hMLH1 is a ubiquitous gene encoding the mismatch repair protein (MMR) MutL protein homolog 1 (MLH1). MLH1 functions by repairing mutations occurring during DNA replication, in normal proliferating cells.
Mismatch Repair Protein (MLH1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissue, as an adjunct to conventional histopathology using non-immunologic histochemical stains. Loss of MLH1 is associated with MMR deficiency and microsatellite instability (MSI) in colorectal and other cancers. Loss of MLH1 in colorectal cancer may assist in identifying patients with possible Lynch syndrome.