Human placenta: immunohistochemical staining for Vascular Endothelial Growth Factor Receptor-3: clone KLT9

Vascular Endothelial Growth Factor Receptor-3

vascular-endothelial-growth-factor-receptor-3

Antigen Background

VEGFR-3 (FLT4) is a receptor tyrosine kinase similar in structure to VEGFR-1 and VEGFR-2 but does not bind VEGF; however, the two known ligands have a high degree of homology to VEGF and are known as VEGF-C and VEGF-D. VEGFR-3 is reported to be found in many tissues including lung, intestine, brain and placenta (syncytiotrophoblasts). Throughout embryogenesis, VEGFR-3 mRNA is expressed in most endothelial cells, whilst being restricted to lymphatic vessels later in development. It appears to play an important role in the normal development of blood and lymphatic vessels. In tumors, expression has been reported in blood capillary endothelium and VEGFR-3 is thought to be involved in angiogenesis during tumor growth.

Disclaimer

Vascular Endothelial Growth Factor Receptor-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • VEGFR3-L-A
    1ml NCL-L-VEGFR-3
    KLT9
    Liquid Concentrate
    NA

Product Specifications

Product Specifications

VEGFR3-L-A
Specialized
KLT9
Liquid Concentrate
No
NA
Mono
Mouse
Analyte Specific Reagent
1ml

Documents

Documents

VEGFR3-L-A

Resources

Resources

Antigen Background

VEGFR-3 (FLT4) is a receptor tyrosine kinase similar in structure to VEGFR-1 and VEGFR-2 but does not bind VEGF; however, the two known ligands have a high degree of homology to VEGF and are known as VEGF-C and VEGF-D. VEGFR-3 is reported to be found in many tissues including lung, intestine, brain and placenta (syncytiotrophoblasts). Throughout embryogenesis, VEGFR-3 mRNA is expressed in most endothelial cells, whilst being restricted to lymphatic vessels later in development. It appears to play an important role in the normal development of blood and lymphatic vessels. In tumors, expression has been reported in blood capillary endothelium and VEGFR-3 is thought to be involved in angiogenesis during tumor growth.

Disclaimer

Vascular Endothelial Growth Factor Receptor-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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