Human thymus: immunohistochemical staining for Terminal Deoxynucleotidyl Transferase. Note nuclear staining for cortical thymic lymphocytes. Terminal deoxynucleotidyl transferase: clone SEN28

Terminal Deoxynucleotidyl Transferase

terminal-deoxynucleotidyl-transferase

Antigen Background

Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase of 58 kD located in the cell nucleus which catalyzes the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is reported to be expressed in primitive T and B lymphocytes of the normal thymus and bone marrow. The identification of TdT-positive cell populations in primary and secondary lymphoid organs during maturation of the immune system is one area of interest but it is the reported occurrence of high levels of enzyme activity in white blood cells and bone marrow in certain leukemias which is of particular interest.


Disclaimer

Terminal Deoxynucleotidyl Transferase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces TDT-339-R-7-CETDT-339-CETDT-339-OTDT-339-STDT-339TDT-339-L-STDT-339-L-CE-STDT-339-CE-S
    TDT-339-L-CE
    1ml NCL-L-TdT-339
    SEN28
    Liquid Concentrate
    P (HIER)
  • PA0339
    7ml TdT Bond RTU Primary
    SEN28
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

TDT-339-L-CE
Hematopathology
SEN28
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0339
Hematopathology
SEN28
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

TDT-339-L-CE
PA0339

Resources

Resources

Antigen Background

Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase of 58 kD located in the cell nucleus which catalyzes the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is reported to be expressed in primitive T and B lymphocytes of the normal thymus and bone marrow. The identification of TdT-positive cell populations in primary and secondary lymphoid organs during maturation of the immune system is one area of interest but it is the reported occurrence of high levels of enzyme activity in white blood cells and bone marrow in certain leukemias which is of particular interest.


Disclaimer

Terminal Deoxynucleotidyl Transferase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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