Breast carcinoma showing neuroendocrine differentiation: immunohistochemical staining for Synaptophysin. Note cytoplasmic staining of tumor cells. Synaptophysin: clone 27G12

Synaptophysin

synaptophysin

Antigen Background

Synaptophysin is an integral membrane glycoprotein with a molecular weight of 38 kD. It is reported to occur in presynaptic vesicles of neurons in brain, spinal cord, retina, in similar vesicles of the adrenal medulla as well as in neuromuscular junctions.<br>Synaptophysin may be involved in synaptic vesicle formation and exocytosis. Synaptophysin is reported to be expressed in a wide spectrum of neuroendocrine tumors including neuroblastomas, ganglioneuroblastomas, phaeochromocytomas, chromaffin and non-chromaffin paragangliomas.<br>Synaptophysin is also reported to be expressed in neuroendocrine tumors of epithelial type including pituitary adenomas, islet cell tumors, medullary carcinomas of thyroid, parathyroid adenomas, carcinoids of the bronchopulmonary and gastrointestinal tracts, neuroendocrine carcinomas of the bronchopulmonary and gastrointestinal tract and neuronendocrine carcinomas of the skin.


Disclaimer

Synaptophysin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces SYNAP-299-R-7SYNAP-299-CESYNAP-299-OSYNAP-299SYNAP-299-CE-SSYNAP-299-LSYNAP-299-R-7-CE
    SYNAP-299-L-CE
    1ml NCL-L-SYNAP-299
    27G12
    Liquid Concentrate
    P (HIER)
  • PA0299
    7ml Synaptoph Bond RTU Primary
    27G12
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

SYNAP-299-L-CE
Head, Neck and Endocrine
27G12
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0299
Head, Neck and Endocrine
27G12
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

SYNAP-299-L-CE
PA0299

Resources

Resources

Antigen Background

Synaptophysin is an integral membrane glycoprotein with a molecular weight of 38 kD. It is reported to occur in presynaptic vesicles of neurons in brain, spinal cord, retina, in similar vesicles of the adrenal medulla as well as in neuromuscular junctions.<br>Synaptophysin may be involved in synaptic vesicle formation and exocytosis. Synaptophysin is reported to be expressed in a wide spectrum of neuroendocrine tumors including neuroblastomas, ganglioneuroblastomas, phaeochromocytomas, chromaffin and non-chromaffin paragangliomas.<br>Synaptophysin is also reported to be expressed in neuroendocrine tumors of epithelial type including pituitary adenomas, islet cell tumors, medullary carcinomas of thyroid, parathyroid adenomas, carcinoids of the bronchopulmonary and gastrointestinal tracts, neuroendocrine carcinomas of the bronchopulmonary and gastrointestinal tract and neuronendocrine carcinomas of the skin.


Disclaimer

Synaptophysin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Recently Viewed

View All