Human lung adenocarcinoma: immunohistochemical staining for Surfactant Protein A. Note intense cytoplasmic staining of type II pneumocytes and alveolar macrophages. Surfactant Protein A: clone 32E12

Surfactant Protein A

surfactant-protein-a

Antigen Background

Pulmonary surfactant plays a critical role in maintaining the structural integrity of the respiratory epithelium by reducing surface tension during expiration. It is a lipoprotein complex which is synthesized and secreted into the alveoli of the lung by type II pneumocytes. Lung surfactant protein-A (SP-A) is a major phospholipid-associated glycoprotein in surfactant and is a member of the C-type lectin superfamily that also inhibits lipid secretion and enhances the uptake of phospholipid by alveolar type II cells. Levels of SP-A in amniotic fluid are reported to reflect the degree of fetal lung maturity and inadequate levels of surfactant at birth, a frequent occurrence in premature infants, results in respiratory failure.


Disclaimer

Surfactant Protein A is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • SP-A-L-U
    1ml NCL-L-SP-A
    32E12
    Liquid Concentrate
    P (HIER)

Product Specifications

Product Specifications

SP-A-L-U
Lung Pathology
32E12
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml

Documents

Documents

SP-A-L-U

Resources

Resources

Antigen Background

Pulmonary surfactant plays a critical role in maintaining the structural integrity of the respiratory epithelium by reducing surface tension during expiration. It is a lipoprotein complex which is synthesized and secreted into the alveoli of the lung by type II pneumocytes. Lung surfactant protein-A (SP-A) is a major phospholipid-associated glycoprotein in surfactant and is a member of the C-type lectin superfamily that also inhibits lipid secretion and enhances the uptake of phospholipid by alveolar type II cells. Levels of SP-A in amniotic fluid are reported to reflect the degree of fetal lung maturity and inadequate levels of surfactant at birth, a frequent occurrence in premature infants, results in respiratory failure.


Disclaimer

Surfactant Protein A is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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