Human striated muscle: immunohistochemical staining for Spectrin. Note membrane staining of muscle fibers. Spectrin: clone RBC2/3D5

Spectrin

spectrin

Antigen Background

Spectrin is a cytoskeletal protein which has some structural homology with dystrophin, the protein that is defective in Duchenne and Becker muscular dystrophy. Subtle membrane damage frequently occurs during the excision and freezing of muscle biopsies. Labeling for spectrin must be used to monitor membrane integrity. NCL-SPEC1 recognizes the beta chain of spectrin in erythrocytes and muscle. NCL-SPEC1 reacts with human beta-spectrin.


Disclaimer

Spectrin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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