Human colon: immunohistochemical staining of Protein Gene Product 9.5. Note the staining in the neuronal elements and the ganglia of the longitudinal and circular smooth muscle. Protein Gene Product 9.5: clone 10A1

Protein Gene Product 9.5

protein-gene-product-95

Antigen Background

Protein gene product (PGP) 9.5 is a neuron-specific protein, structurally and immunologically distinct from neuron specific enolase. The protein which has a molecular weight of 27 kD was first identified by high resolution two dimensional PAGE. PGP9.5 expression has been reported in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. PGP9.5 is a member of the ubiquitin C-terminal hydroxylase family and is also concentrated within inclusion bodies suggesting that such structures may be metabolically active regions of the cells.

Disclaimer

Protein Gene Product 9.5 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • PGP9.5-L-CE
    1ml NCL-L-PGP9.5
    10A1
    Liquid Concentrate
    P (HIER)
  • PA0286
    7ml PGP 9.5 Bond RTU Primary
    10A1
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

PGP9.5-L-CE
Neuropathology
10A1
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0286
Neuropathology
10A1
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

PGP9.5-L-CE
PA0286

Resources

Resources

Antigen Background

Protein gene product (PGP) 9.5 is a neuron-specific protein, structurally and immunologically distinct from neuron specific enolase. The protein which has a molecular weight of 27 kD was first identified by high resolution two dimensional PAGE. PGP9.5 expression has been reported in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. PGP9.5 is a member of the ubiquitin C-terminal hydroxylase family and is also concentrated within inclusion bodies suggesting that such structures may be metabolically active regions of the cells.

Disclaimer

Protein Gene Product 9.5 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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