Human prostate: immunohistochemical staining for Prostate Specific Membrane Antigen (PSMA): clone 1D6

Prostate Specific Membrane Antigen

prostate-specific-membrane-antigen

Antigen Background

The prostate specific membrane antigen (PSMA) is expressed as a 750 amino acid glycoprotein but may also be found as PSM, a form of the protein missing the first 57 amino acids. PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase. Reports suggest that PSMA expression may correlate with tumor burden and serve as an indicator of metastatic involvement. The cellular localization of PSMA contrasts with that of prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) that are secreted proteins.

Disclaimer

Prostate Specific Membrane Antigen is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.  


Analyte Specific Reagent Statement

Analyte Specific Reagent. Analytical and performance characteristics are not established. 

  • PSMA-L
    1ml NCL-L-PSMA
    1D6
    Liquid Concentrate
    P (HIER)
  • PSMA-L-A
    1ml NCL-L-PSMA
    1D6
    Liquid Concentrate
    P (HIER)

Product Specifications

Product Specifications

PSMA-L
Uropathology
1D6
Liquid Concentrate
No
P (HIER)
Mono
Mouse
Research Use Only
1ml
PSMA-L-A
Uropathology
1D6
Liquid Concentrate
No
P (HIER)
Mono
Mouse
Analyte Specific Reagent
1ml

Documents

Documents

PSMA-L
PSMA-L-A

Resources

Resources

Antigen Background

The prostate specific membrane antigen (PSMA) is expressed as a 750 amino acid glycoprotein but may also be found as PSM, a form of the protein missing the first 57 amino acids. PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase. Reports suggest that PSMA expression may correlate with tumor burden and serve as an indicator of metastatic involvement. The cellular localization of PSMA contrasts with that of prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) that are secreted proteins.

Disclaimer

Prostate Specific Membrane Antigen is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.  


Analyte Specific Reagent Statement

Analyte Specific Reagent. Analytical and performance characteristics are not established. 

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