Human tonsil: immunohistochemical staining for Oct-2. Note strong staining of germinal centre B-cells. Oct-2: clone Oct-207

Oct-2

oct-2

Antigen Background

Oct-2 is a transcription factor belonging to the POU homeo-domain family that binds to the Ig gene octamer sites regulating B cell specific genes. It is dependent on the activity of B cell restricted coactivators such as BOB.1/OBF.1. Oct-2 protein expression is not restricted to B cells, although expression levels are much higher in these cells. Reports indicate that germinal center B cells shows higher expression for Oct-2 and BOB.1/OBF.1. In addition, Oct-2 expression is reported to be significantly greater in germinal center derived lymphomas, although other B cell lymphomas also display high levels of expression. Reed Sternberg (RS) cells represent the malignant cells in classical Hodgkin's disease and are derived from germinal center B cells. In a number of these cases, cells do not express immunoglobulin due to the presence of crippling mutations within the Ig genes. As Ig gene expression in B cells also requires an interaction between octamer sites and the transactivating factors Oct-2 and BOB.1, the absence of both Oct-2 and BOB.1 expression represents a novel mechanism for immunoglobulin gene deregulation in RS cells.

Disclaimer

Oct-2 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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