Human lung: immunohistochemical staining for Napsin A. Note cytoplasmic staining of pneumocytes and alveolar macrophages. Napsin A: clone IP64

Napsin A

napsin-a

Antigen Background

Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors.

Napsin A is reported to be predominantly expressed in lamellar bodies of type II pneumocytes, secondary lysosomes of alveolar macrophages, respiratory epithelium of terminal and respiratory bronchioles, plasma cells, within a subset of lymphocytes in normal lung, as well as in epithelial cells of renal tubules in normal kidney and is weakly expressed in normal spleen.

Studies have reported that Napsin A is expressed in 90% of primary lung adenocarcinomas.


Disclaimer

Napsin A is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces NAPSINA-L-SNAPSINA-LNAPSINA-L-CE-S
    NAPSINA-L-CE
    1ml NCL-L-Napsin A
    IP64
    Liquid Concentrate
    P (HIER)
  • PA0805
    7ML Napsin A (MRQ-60 Mab) 'CM'
  • PA0064
    7ml Napsin A (IP64) Bond RTU Primary
    IP64
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

NAPSINA-L-CE
Lung Pathology
IP64
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0805
PA0064
Lung Pathology
IP64
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

NAPSINA-L-CE
PA0064

Resources

Resources

Antigen Background

Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors.

Napsin A is reported to be predominantly expressed in lamellar bodies of type II pneumocytes, secondary lysosomes of alveolar macrophages, respiratory epithelium of terminal and respiratory bronchioles, plasma cells, within a subset of lymphocytes in normal lung, as well as in epithelial cells of renal tubules in normal kidney and is weakly expressed in normal spleen.

Studies have reported that Napsin A is expressed in 90% of primary lung adenocarcinomas.


Disclaimer

Napsin A is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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