Human rhabdomyosarcoma: immunohistochemical staining for Myf-4 protein. Note staining of a proportion of tumor cell nuclei. Myogenin (Myf-4): clone LO26

Myogenin (Myf-4)

myogenin-myf-4

Antigen Background

Rhabdomyosarcomas are a class of myoblast-derived soft tissue sarcomas that usually express a number of muscle-specific genes and primarily affect children and young adults. Differentiation of myogenic cells is controlled by a set of regulatory genes including MyoD1, myogenin, Myf-5 and Myf-6. Myf-4 is the human homolog of myogenin. Its gene product, together with that of Myf-3, accumulates in the nucleus of differentiated cells.

Disclaimer

Myogenin (Myf-4) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces MYF-4MYF-4-LMYF-4-SMYF-4-CE-SMYF-4-CE
    MYF-4-L-CE
    1ML NCL-L-Myf-4
    LO26
    Liquid Concentrate
    P (HIER)
  • PA0226
    7ml Myf-4 Bond RTU Primary
    LO26
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

MYF-4-L-CE
Muscle Pathology
LO26
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0226
Muscle Pathology
LO26
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

MYF-4-L-CE
PA0226

Resources

Resources

Antigen Background

Rhabdomyosarcomas are a class of myoblast-derived soft tissue sarcomas that usually express a number of muscle-specific genes and primarily affect children and young adults. Differentiation of myogenic cells is controlled by a set of regulatory genes including MyoD1, myogenin, Myf-5 and Myf-6. Myf-4 is the human homolog of myogenin. Its gene product, together with that of Myf-3, accumulates in the nucleus of differentiated cells.

Disclaimer

Myogenin (Myf-4) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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