Human tonsil: immunohistochemical staining for MUM-1. Note nuclear staining of B cells showing lymphoplasmacytic differentiation. Multiple Myeloma Oncogene 1: clone EAU32

Multiple Myeloma Oncogene 1 (MUM-1)

multiple-myeloma-oncogene-1-mum-1

Antigen Background

The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells).

Disclaimer

Multiple Myeloma Oncogene 1 (MUM-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • MUM1-L-CE
    1ml NCL-L-MUM1
    EAU32
    Liquid Concentrate
    P (HIER)
  • PA0129
    7ml MUM1 Bond RTU Primary
    EAU32
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

MUM1-L-CE
Hematopathology
EAU32
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0129
Hematopathology
EAU32
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

MUM1-L-CE
PA0129

Resources

Resources

Antigen Background

The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells).

Disclaimer

Multiple Myeloma Oncogene 1 (MUM-1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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