Immunohistochemical staining for mismatch repair protein (MSH2). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MSH2): clone 79H11.

Mismatch Repair Protein (MSH2)

Antigen Background
Mismatch repair gene MutS Homolog 2 is a ubiquitous gene encoding the mismatch repair protein (MMR) MutS protein homolog 2 (MSH2). MSH2 functions by repairing mutations occurring during DNA replication, in normal proliferating cells.

Disclaimer
Mismatch Repair Protein (MSH2) is recommended for the detection of specific antigens of interest in normal and neoplastic tissue, as an adjunct to conventional histopathology using non-immunologic histochemical stains. Loss of MSH2 is associated with MMR deficiency and microsatellite instability (MSI) in colorectal and other cancers. Loss of MSH2 in colorectal cancer may assist in identifying patients with possible Lynch syndrome.

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The BOND MMR Antibody Panel is now available for clinical use on the BOND-III and BOND-MAX Immunohistochemistry (IHC) automated instruments as a Class II with the product codes PA0988-U, PA0989-U, PA0990-U, PA0991-U

Products

Products

PA0989-U
7ml MSH2 (79H11) Bond RTU Primary
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Downloads

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PA0989-U

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