Immunohistochemical staining for mismatch repair protein (MLH1). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MLH1): clone ES05.
Mismatch Repair Protein (MLH1)
mismatch-repair-protein-mlh1
Antigen Background
Mismatch repair gene hMLH1 is a ubiquitous gene encoding the mismatch repair protein (MMR) MutL protein homolog 1 (MLH1). MLH1 functions by repairing mutations occurring during DNA replication, in normal proliferating cells.
Disclaimer
Mismatch Repair Protein (MLH1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissue, as an adjunct to conventional histopathology using non-immunologic histochemical stains.