Colorectal carcinoma: immunohistochemical staining for mismatch repair protein (MLH1). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MLH1): clone ES05.

Mismatch Repair Protein (MLH1)

mismatch-repair-protein-mlh1

Antigen Background

MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in alterations to microsatellite repeats, often referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in some forms of colon cancer, a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.

Disclaimer

Mismatch Repair Protein (MLH1) is a recommended for the detection of specific antigens of interest in normal and neoplastic tissue, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces MLH1-L-CE-SMLH1-LMLH1-L-S
    MLH1-L-CE
    1ml NCL-L-MLH1
    ES05
    Liquid Concentrate
    P (HIER)
  • PA0610
    7ml MLH1 Bond RTU Primary
    ES05
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

MLH1-L-CE
Gastrointestinal Pathology
ES05
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0610
Gastrointestinal Pathology
ES05
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

MLH1-L-CE
PA0610

Resources

Resources

Antigen Background

MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. During DNA replication, strand misalignment can occur resulting in alterations to microsatellite repeats, often referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in some forms of colon cancer, a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.

Disclaimer

Mismatch Repair Protein (MLH1) is a recommended for the detection of specific antigens of interest in normal and neoplastic tissue, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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