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Human squamous cell carcinoma: immunohistochemical staining for mismatch repair protein (MLH1). Note nuclear staining in a high proportion of malignant cells. Mismatch Repair Protein (MLH1): clone ES05
Mismatch Repair Protein (MLH1)
mismatch-repair-protein-mlh1
Antigen Background
MLH1, a mismatch repair protein involved in maintaining the integrity of genetic information, alongside MSH2, MSH6 and PMS2. Defects in DNA repair pathways have been linked to human carcinogenesis. Mutations in the MLH1 gene have been reported to be found in some forms of colon cancer, a subset of sporadic carcinomas and breast cancer. Loss of expression of MLH1 has also been reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric carcinoma and ovarian carcinoma.
Disclaimer
Mismatch Repair Protein (MLH1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.