Mammaglobin is a 93 kDa glycoprotein that belongs to the uteroglobin family of proteins. It was first described in 1996 and found to be overexpressed in breast cancer. Published reports suggest a role for mammaglobin in the diagnosis of metastatic breast carcinoma.
Mammaglobin has been suggested as a useful marker for carcinomas of unknown primary origin, with expression unaltered from the primary site. Additional published data suggests a role for mammaglobin in the migration and invasion of breast cancer cells.
Mammaglobin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.