Mantle cell lymphoma: immunohistochemical staining for Immunoglobulin D. Note the mantle cell tumor cells show moderate staining for Immunoglobulin D, with a stronger reaction seen in plasma cells. Immunoglobulin D: clone DRN1C

Immunoglobulin D

immunoglobulin-d

Antigen Background

IgD, together with IgM, are the major immunoglobulins expressed on the surface of B cells where it seems they may operate as mutually interacting antigen receptors for the control of lymphocyte activation and suppression. The greater susceptibility of IgD to proteolysis in combination with antigen could well be implicated in such a function.

Product Specific Information

The use of PBS-based diluents may result in increased background staining. Clone DRN1C was developed to produce reduced background staining that is associated with polyclonal antibodies on paraffin sections.

Disclaimer

Immunoglobulin D is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces IGDPIGD-L-CE-S
    IGD-L-CE
    1ml NCL-L-IgD
    DRN1C
    Liquid Concentrate
    P (HIER)
  • PA0061
    7ml IgD (DRN1C) Bond RTU Primary
    DRN1C
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

IGD-L-CE
Hematopathology
DRN1C
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0061
Hematopathology
DRN1C
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

IGD-L-CE
PA0061

Resources

Resources

Antigen Background

IgD, together with IgM, are the major immunoglobulins expressed on the surface of B cells where it seems they may operate as mutually interacting antigen receptors for the control of lymphocyte activation and suppression. The greater susceptibility of IgD to proteolysis in combination with antigen could well be implicated in such a function.

Product Specific Information

The use of PBS-based diluents may result in increased background staining. Clone DRN1C was developed to produce reduced background staining that is associated with polyclonal antibodies on paraffin sections.

Disclaimer

Immunoglobulin D is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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