Human tonsil: immunohistochemical staining for Granzyme B: clone 11F1

Granzyme B

granzyme-b

Antigen Background

Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.

Disclaimer

Granzyme B is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Products

Products

GRAN-B-L-CE
1ml NCL-L-GRAN-B
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This item replaces GRAN-B-CEGRAN-B-R-7-CEGRAN-B-CE-SGRAN-BGRAN-B-S
11F1
Hematopathology
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0291
7ml Granzyme B Bond RTU Prim
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11F1
Hematopathology
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

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GRAN-B-L-CE

PA0291

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