Human liver: immunohistochemical staining for GSTpi. Note staining of bile ducts. Glutathione S-transferase pi: clone LW29

Glutathione S-Transferase (GST) Antibody

glutathione-s-transferase-gst-antibody

Antigen Background

The glutathione S-transferases (GSTs) are a multigene family of isoenzymes which catalyze the conjugation of glutathione to electrophilic substrates. These enzymes are involved in the detoxification of both endogenous and exogenous electrophiles which can react with cellular components such as DNA. The modification of DNA by reactive compounds can initiate carcinogenesis and the GSTs are believed to play a role in neutralizing carcinogens. The cytosolic GST isoenzymes have been classified into four evolutionary classes; alpha, mu, pi and theta. These isoenzymes are reported to be singly or multi-expressed in a variety of normal tissues, including stomach, bowel, brain, heart, liver, pancreas, breast, kidney and skin at differing levels. In gastric cancers, the levels of GSTalpha and pi are reported to differ from normal gastric tissue with GSTalpha showing decreased levels and GSTpi increased levels.

Disclaimer

Glutathione S-Transferase (GST) Antibody is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces GSTPI-438-U
    GSTPI-438-L-U
    1ml NCL-L-GSTpi-438
    LW29
    Liquid Concentrate
    P

Product Specifications

Product Specifications

GSTPI-438-L-U
Specialized
LW29
Liquid Concentrate
No
P
Mono
Mouse
In Vitro Diagnostic Use
1ml

Documents

Documents

GSTPI-438-L-U

Resources

Resources

Antigen Background

The glutathione S-transferases (GSTs) are a multigene family of isoenzymes which catalyze the conjugation of glutathione to electrophilic substrates. These enzymes are involved in the detoxification of both endogenous and exogenous electrophiles which can react with cellular components such as DNA. The modification of DNA by reactive compounds can initiate carcinogenesis and the GSTs are believed to play a role in neutralizing carcinogens. The cytosolic GST isoenzymes have been classified into four evolutionary classes; alpha, mu, pi and theta. These isoenzymes are reported to be singly or multi-expressed in a variety of normal tissues, including stomach, bowel, brain, heart, liver, pancreas, breast, kidney and skin at differing levels. In gastric cancers, the levels of GSTalpha and pi are reported to differ from normal gastric tissue with GSTalpha showing decreased levels and GSTpi increased levels.

Disclaimer

Glutathione S-Transferase (GST) Antibody is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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