GATA3

Antigen Background

GATA3 is a zinc-finger transcription factor and one of six members of the GATA family, characterized by its ability to bind G‑A‑T‑A nucleotide sequences within target gene promoters to activate or repress gene transcription. GATA3 plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types including breast epithelium, kidney, and urothelium. Although GATA3 expression is primarily seen in breast carcinoma and urothelial carcinoma, it is also found to be expressed in epithelial or mesenchymal neoplasms.

Disclaimer

GATA3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.